A new study used proteomics to decipher the mechanisms of action of 875 drugs, providing a valuable resource for understanding how drugs work and developing more targeted and effective therapies. — Introduction It is widely recognized that many (small molecule) drugs exhibit polypharmacology, whereby a single drug can affect multiple (protein) targets, resulting in off-target or undesired side effects. Identifying the protein targets or understanding drug mechanism of action (MOA) — how these small molecule compounds act to induce pharmacologic changes, however…